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Developmental Neurobiology

Characterisation of paediatric brain tumours to improve targeted treatment design

Work in the Gilbertson, Pathania and Creixell groups, and as part of the CRUK Children's Brain Tumour Centre of Excellence looks at: 

  • Molecular subtypes predictive for treatment response

  • Integrate mouse models and patient samples to better characterise tumour subtypes and the developing brain

  • Optimise pre-clinical drug testing for novel/repurposed treatments

Develop an integrated cancer medicine pipeline to predict tumour behaviour and treatment response for paediatric brain tumours

The Gilbertson, Pathania and Creixell groups within the CRUK Children's Brain Tumour Centre of Excellence are integrating molecular, radiological and clinical data to predict treatment failure, optimising pipelines for second line therapies and characterising neurobiological treatment escape.



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